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Mitochondrial neurogastrointestinal encephalomyopathy Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), an autosomal recessive disorder first identified in 1978, 486 is characterized by a range of clinical symptoms including cachexia, gastrointestinal dysmotility, peripheral neuropathy, ophthalmoparesis, and leukoencephalopathy

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These same cytokines play a central role in the pathogenesis of rheumatoid arthritis, where they contribute to joint inflammation, cartilage degradation, and bone erosion

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