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Additionally, metformin delayed the progression of cirrhosis by regulating the activation and proliferation of hepatic stellate cells (HSCs) via the TGF-1/Smad3 and succinate-GPR91 pathways

"Most importantly, when you look at the global need, we expect that there are more than one billion people across the globe that are suffering from obesity," Jonsson said

Although many theories have been proposed to explain the pathogenesis of PCOS, recent studies have increasingly linked OS to various aspects of the condition (124, 132)

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