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Even Avecho Biotechnology (formerly Phosphagenics), a company who wanted to repurposed AOD-9604 as a transdermal formulation, knew why the clinical trials failed: AOD9604s delivery could have been the key issue

That mechanistic separateness is precisely why the two are combined rather than compared

Compounding allows the prescriber to adjust the active ingredient profile based on scar type (hypertrophic, keloid, post-surgical) and patient response

However, increased parathyroid hormone levels combined with decreased levels of calcitonin (and estrogens in women) can lead to osteoporosis as PTH stimulates demineralization of bones to increase blood calcium levels