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Oral semaglutide showed superiority over placebo [35], empagliflozin [36], and sitagliptin [37] and noninferiority over liraglutide [38] in reducing HbA1c levels in T2DM patients
Ozempic (semaglutide) is contraindicated in patients with a family history of medullary thyroid cancer (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
Wegovy (the weight management indication) has broader coverage than Ozempic for non-diabetic patients, but many plans still exclude weight loss medications or require prior authorization
Kannengiesser K, Maaser C, Heidemann J, Luegering A, Ross M, Brzoska T, Bhm M, Luger TA, Domschke W, Kucharzik T Melanocortin-Derived Tripeptide KPV Has Anti-Inflammatory Potential in Murine Models of Inflammatory Bowel Disease Inflammatory Bowel Diseases (2008) 5
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