Substrate specificity profiling of natural and evolved proteases To assess the substrate preferences of a protease in a broad and rapid manner, we developed a method for profiling protease activity on a substrate library by adapting the PACE selection circuit
Figure 1: Changes in A) sociability index, B) social novelty index, C) # USVs evoked, D) % marbles buried, E) grooming time in seconds between control mice and mice treated with MT-II Finally, the study explored differences in oxytocin receptor expression in the brains of MIA mice compared to normal C57BL/6J mice
Proteoliposomes as tool for assaying membrane transporter functions and interactions with xenobiotics
Clinical studies have reported that the damaged structure and dysfunction of mitochondria (56) including inefficient ATP production, excessive ROS (5760), and decreases in mitochondrial biogenesis and activity of ATP synthase (61, 62) were clearly observed in patients with obesity or diabetes