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Pre-existing gastrointestinal disorders, pancreatic history, thyroid disease, kidney function, and medication interactions significantly affect how your body tolerates and responds to GLP-1 therapy over months and years
Subsequent reviews have reinforced this finding, suggesting GLP-1s may dampen reward signaling in the brains dopamine pathways, which are involved in addiction and compulsive behaviors (Kalra et al., 2024
Clinical trials have demonstrated significant weight loss with injectable tirzepatide, which is why many doctors consider it the gold standard for GLP-1 medication
Mann JFE, rsted DD, Brown-Frandsen K, Marso SP, Poulter NR, Rasmussen S, Torne K, Zinman B, Buse JB
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