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Another report demonstrated that, mediated by 64 integrin, the activation of SRC and STAT3 could inhibit ACSL4 expression, leading to the protection of adherent epithelial and carcinoma cells form erastin-induced ferroptosis ( Rb The retinoblastoma (Rb) protein is the founding member of a protein family that exerts a strong regulatory function on the transcription of various genes in eukaryotes (Knudsen and Knudsen, 2008)