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- Upon thawing, the protein refolds incorrectly or aggregates into non-functional clumps
Epitalon treatment reduced intracellular reactive oxygen species, decreased spindle defects and abnormal cortical granule distribution, and increased mitochondrial membrane potential and mitochondrial DNA copy number
What this means for dosing calculations: the clinical trial protocols use fixed escalation schedules with specific dose targets (typically 8mg or 12mg maintenance)
I 2 = 96.4%, p 30 kg/m 2 ) [WMD = 1.28
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