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However, some people have difficulty absorbing vitamin B12 from their diet, including dietary restrictions, certain medical conditions like pernicious anemia, or medications that interfere with B12 absorption

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This argument is plausible it reflects a well-documented problem in drug development where unpatentable compounds struggle to attract industry funding regardless of their scientific merit but it should be noted that this explanation, while widely discussed, has not been formally established in the published literature as the primary reason for the evidence gap