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12-week community planning example Phase Observation phase Weeks 14 Daily amount 300 mcg Phase total 8.4 mg Phase Later phase Weeks 512 Daily amount 500 mcg Phase total 28 mg Phase Full cycle Weeks 112 Daily amount Mixed schedule Phase total 36.4 mg METAOD005 also lasted 12 weeks, but it tested oral doses from 1 to 30 mg per day