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Figure 2 The clinically most relevant and important action of DPP-4 inhibitors is the endogenous elevation of the incretin hormone concentration of GLP-1 that consecutively leads to a glucose-dependent stimulation of insulin secretion and an inhibition of glucagon secretion (10)

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Therefore, these findings suggest that gliptins have favorable effects on erectile function, although further investigations are needed to understand whether these effects are due to better glycemic control or to a reduction in the diabetes-associated inflammatory state, and/or alternatively to a direct effect on penile endothelial cells

doi: 10.1002/pmic.201500291 100 LiuLArunAEllisLPeritoreCDonmezG