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However, cardiovascular safety trials in type 2 diabetes patients, the majority presenting cardiovascular disease and excess weight, showed that GLP-1 receptor agonists were indeed capable of decreasing cardiovascular risk

LY3437943, a Novel Triple Glucagon, GIP, and GLP-1 Receptor Agonist for Glycemic Control and Weight Loss: From Discovery to Clinical Proof of Concept

Therefore, it is urgent to validate the therapeutic effect of GLP-1R agonists with large-scale studies and well-designed randomized, controlled trials

In trials, retatrutide showed somewhat higher weight loss (~28.7% vs ~22.5%) and much higher liver fat reduction