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The principal neurological function regulated by GLP-1RA could be summarized as follows ( Figure 2 ): (1) GLP-1RA liraglutide and exendin-4 effectively inhibited neuronal apoptosis ( Figure 2 4 GLP-1RA reduced the risk of stroke in T2D patients clinically As a new type of hypoglycemic drug, GLP-RAs are currently mainly used in clinical practice to evaluate the prognosis of various complications in T2D patients, such as stroke, kidney injury, fatty liver, and cardiovascular disease (43)

Currently, there are no known severe medication interactions

The agency applied the four-factor framework set out in 21 CFR 216.23(c), covering physical and chemical characterisation, safety, evidence of effectiveness, and historical use

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