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This may be explained by the findings of Albares and colleagues, Guinot and colleagues, and Kang and colleagues , who reported that pregnancy, use of hormonal contraception and lack of use of sunscreen are aggravating factors of melasma due to increase number and activity of melanocyte in epidermis

Hydroxyl radicals, among the most destructive ROS, can inflict severe oxidative damage on DNA, proteins, and lipids within sperm cells

Accessed 04/22/19