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This is why patients with neurological involvement are often maintained on a more frequent schedule (every 2 months rather than every 3 months)

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Stacking & Combinations Because its mechanism is NAD+ preservation, the logical research pairing is with the NAD+ pathway : in some research framings, an NNMT inhibitor like 5-Amino-1MQ is discussed alongside NAD+ precursors, on the reasoning that inhibiting the enzyme that drains NAD+ and supplying more NAD+ substrate address the same bottleneck from two directions