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Oral vs injectable efficacy: Clinical trials show injectable semaglutide produces approximately 15% to 17% total body weight loss at 68 weeks, while oral semaglutide (Rybelsus) produces approximately 10% to 12% weight loss at the same timepoint (Wilding et al., NEJM 2021

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Ozempic - Clinical Pharmacology 12.1 Ozempic Mechanism of Action Semaglutide is a GLP-1 analogue with 94% sequence homology to human GLP-1