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One possible alternative is medication that acts simultaneously on several receptors as so-called multifunctional agonists
When one health system compared more than a thousand bariatric-surgery patients with about two thousand people on semaglutide or tirzepatide, surgery caused more total weight loss and more absolute muscle loss, but the share that came off as lean stayed in the same modest range for both (2026 cohort)
The supplementation must be attentive as the reference ranges of Se blood levels are narrow, and the risk of insufficient or toxic supplementation is possible (245, 246)
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