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The graphical abstracts were created with BioRender software ( Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

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MK-677, by contrast, is a non-peptide spiroindoline compound that mimics ghrelin at the GHS-R1a receptor but with 24-hour half-life and oral bioavailability

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