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Peripherally, they primarily act on the pancreas and gastrointestinal tract, stimulating insulin secretion and inhibiting glucagon secretion when blood glucose levels rise, thereby exerting a hypoglycemic effect [60]
Most people begin noticing effects within the first 2 to 4 weeks, though significant weight loss typically becomes apparent after 8 to 12 weeks
doi: 10.1097/CCM.0000000000004625 22 BharathL
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