Retatrutide carries the side-effect profile of the GLP-1/GIP class nausea, vomiting, diarrhoea, constipation plus the class-level concerns we know from Mounjaro and Wegovy: gallbladder disease, pancreatitis, kidney injury from severe dehydration, and a possible thyroid C-cell tumour signal seen in rodent studies
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The changes in the levels of various lipid species that result from the imbalance between lipolysis/lipid uptake/lipogenesis and lipid oxidation/secretion can cause organellar dysfunction, e.g
Another study found a 0.83% overall risk of these events in GLP-1 RA users compared to a 0.63% overall risk of these events in non-GLP-1 RA controls (Bloomgarden 2024)