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Too close to home Source: The Onion So overall, these results support the idea that GLP-1 drugs may have multi-system benefits beyond glycemic control, including immune and neuroprotection pathways

In this sense, rebound headache is very common, because migraine attacks can last for 72 hours (or even longer) and treatments for migraine attacks can wear off after a few hours, so its not unusual to have to take several doses of acute medication to completely treat a single migraine attack