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Similar to GIP, GLP-1 led to a notable suppression of the bone resorption marker CTX-1
Key variants such as FTO rs9939609 and MC4R rs17782313 affect appetite and metabolic set point, while GLP1R rs6923761 influences receptor sensitivity and signaling efficiency
In addition, Caveolin-1 (Cav-1), a 21-kDa integral plasma membrane protein is a well-known negative regulator of eNOS activity in vascular endothelial cells 17,18,19,20,21,22
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