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Clinical decisions need to rest on solid and objective data, especially for medications that affect up to 2% of patients
Corresponding Author: Mohsan Ali, MBBS, King Edward Medical University, St 12, Wapda Town, Phase #1, Lahore, Pakistan ([email protected])
Later, in the 1980s, the development of high-pressure liquid chromatography methods allowed for rapid determination of homocysteine concentrations in 1000s of samples, thus paving the way for epidemiological studies that revealed significant associations between relatively small elevations of homocysteine in blood and cardiovascular, cerebrovascular, and peripheral vascular diseases (7, 46)