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Side effects B12 injections are generally considered safe with minimal side effects when administered appropriately
For individuals with type 2 diabetes, this effect is crucial for managing their condition
A1C -1.5% at 12 mg (-1.6% at 9 mg) TRIUMPH-3 obesity with established cardiovascular disease (July 23, 2026) 22.6% weight loss at 12 mg over 80 weeks ADA 86th Scientific Sessions (Jun 6-10, 2026, New Orleans) the full TRIUMPH-1 + TRANSCEND-T2D-1 panel, the most detailed public presentation of the Phase 3 data see our ADA 2026 retatrutide coverage Still expected: TRIUMPH-5 (head-to-head vs tirzepatide, NCT06662383): Phase 3 obesity efficacy comparison
In clinical trials of Wegovy, discontinuation due to gastrointestinal side effects occurred in approximately 4.5% of participants, while for Zepbound, discontinuation rates due to adverse events (primarily gastrointestinal) ranged from 4.3% to 7.1% depending on dose
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