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Methods Study approval All the related experiments and protocols used in these studies were approved by the Ethical Committees of the University of Cordoba and Junta de Andalusia (Spain), according to EU normative for the use and care of experimental animals (EU Directive 2010/63/UE, September 2010)

Since the capacity of GR1 in the Arabidopsis cytosol is large and far from limiting under normal growth conditions 63 , inhibition of GR1 by (hyper)oxidation of catalytic or regulatory cysteine residues provide a plausible hypothesis 64 either as a result of oxidative damage or as a mechanism to safeguard NADP redox status, similar to what has previously been observed for peroxiredoxins 50,65

These effects complement GLP-1 activation because GLP-1 itself modulates insulin secretion from pancreatic beta cells

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