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"The term 'Ozempic face' refers to the changes in the face that can happen with rapid weight loss," Vinni Makin, MD, told Cleveland Clinic in 2025
50 A recent meta-analysis including thirteen RCTs has shown that semaglutide and tirzepatide treatment significantly increases GI side effects such as nausea, vomiting, diarrhea, and constipation in obese individuals without diabetes compared to control groups
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