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The function of HO-1 in inflammatory reaction In various experimental models of inflammation, HO-1 induction produces favorable effects

For instance, central administration of GLP-1R agonists increases the ability of insulin to suppress endogenous glucose production (Knauf et al., The endogenous GLP-1 system in the regulation of energy homeostasis The endogenous GLP-1 system is densely populated in areas that control energy homeostasis placing it in the neuroanatomical position to regulate food intake and body weight

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The monitoring schedule should be individualized based on treatment indication, baseline comorbidities, and patient-specific factors, though general frameworks provide useful guidance