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To date, long-term studies show sustained benefits and no significant safety concerns, although researchers continue to monitor effects on muscle mass, bone health, and mental well-being as more people use them for longer periods

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Furthermore, decreased bacterial richness has been linked to high carbohydrate 73 and high-fat/low-protein concentrations 74 , as found in the lean and Western diets, respectively, the latter result only in old-aged rats 74