In patients with severe heart failure (NYHA Class IV), spironolactone has been shown to improve overall survival and NYHA functional class, and to reduce hospitalizations when added to conventional therapy (e.g., ACE inhibitor, loop diuretic, digoxin)
Claims described as "according to the brand" or "brand-stated" reflect what the brand has publicly stated and haven't been independently substantiated by this publication
Excess 11-oxygenated androgens in women with severe insulin resistance are mediated by adrenal insulin receptor signaling
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