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312 During the thawing phase of cryoablation, tumor cells within the ice ball release antigens, nucleoproteins, and cytokines, recruiting macrophages and NK cells to stimulate an immune response
Eventually, a plateau occurs
More specifically, heat stress may first trigger proteostasis disruption, mitochondrial dysfunction, and ROS accumulation, followed by aggravated DNA damage, disruption of the bloodtestis barrier, and activation of apoptotic responses
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