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& Sondek, J
The potential molecular pathways that can be targeted include IL-4-IL-13-JAK-STAT-MAP kinases, adiponectin-iNOS-NF-B, PGD2-CRTH2, IFNs-RIG, Wnt/-catenin-FAM13A, FOXC1-miR-PI3K/AKT, JNK-Gal-7, Nrf2-ROS, Foxp3-RORt, CysLTR, AMP, Fas-FasL, PTHrP/PPAR, PAI-1, FcRI-LAT-SLP-76, Tim-3-Gal-9, TLRs-MyD88, PAR2, and Keap1/Nrf2/ARE
Recall the two roles: NAD+ keeps the cellular machinery powered, while a peptide is the message telling a cell what to build or repair
That stability profile is the main reason it appears so frequently in preclinical literature
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