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With intramuscular injections of B12, any excess will result in high levels within your blood so you may experience side effects such as headache, dizziness, tiredness, or gastrointestinal issues including nausea, until your body has metabolised any excess through your kidneys enroute to excretion via urine

Add differing placebo responses 0.4% in the eloralintide trial versus 2.3% and 3.0% in the cagrilintide trials and the placebo-adjusted deltas shift again

Subcutaneous injection offers bioavailability of approximately 15-20% based on animal data, while intramuscular administration may provide 45-50% bioavailability in some species

But what is happening right now is not the adoption of a promising therapy