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Important scope note: virtually all mechanistic data on BPC-157 are derived from in vitro assays or rodent (rat, mouse) injury models

Lancet 2021;397:16879.ArticlePubMed 102

Phosphonate-based irreversible inhibitors of human -glutamyl transpeptidase (GGT)

Although its effectiveness and safety were confirmed at recommended doses, the APAP overdose causes hepatotoxicity that leads to acute liver failure (ALF) (Bunchorntavakul and Reddy, 2018)