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Other common gastrointestinal effects include: Diarrhea Constipation Abdominal pain or cramping Bloating and gas Acid reflux or heartburn Decreased appetite (this is both a therapeutic effect and a side effect) Most of these effects are transient

Quick Take (TLDR) Mostly animal and in vitro data plus multiple very small uncontrolled human reports (knee pain case series n=16, interstitial cystitis pilot n=12, 2subject IV infusion) and no randomized controlled trials or published human pharmacokinetic profiles

This is why dosing typically occurs weekly rather than daily, a significant advantage for research protocols and compliance