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Finally, I saw this tweet by Nithin Kamath of Zerodha, on how GLP-1 drugs arent selling as planned, and I figured this is a good time to finally write this post: A few months ago, at a party, one of the guests looked unusually thin (and not in a good way - slightly sickly thin)

Recently, it was observed that canagliflozin promotes AMPK activity by inhibiting mitochondrial respiration in embryonic kidney cells and mouse cells ( Studies in vitro and in vivo have demonstrated the inhibitor effect of canagliflozin on TC cells

Those distinctions are exactly the kind of current, compound-specific detail a responsible clinician must verify rather than assume

Receptor Binding and Selectivity Differences The receptor binding characteristics of GLP-1 receptor peptides demonstrate remarkable selectivity and specificity that has been refined through decades of molecular engineering