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Mitophagy, in particular, serves as a key mechanism for maintaining metabolic homeostasis by selectively removing damaged mitochondria and limiting the accumulation of ROS [47].In CRC, the PINK1Parkin-mediated mitophagy pathway and Drp1-driven mitochondrial fission have been shown to act in concert to preserve mitochondrial quality under chemotherapeutic stress [48]
For example, in both neurodegenerative diseases like Alzheimer's and Parkinson's, the presence of fewer bacteria generating SCFA and the increased density of proinflammatory microbes lead to neuroinflammation and cognitive decline
In addition, we conducted two post-hoc partial correlation analyses to examine possible confounding effects of age or TSH level
Contextual metabolism: Secretagogue-induced GH pulses are accompanied by normal diurnal variation in insulin and cortisol, maintaining a physiologic environment less conducive to unregulated growth signaling
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