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Timeline from published animal studies What the published research timelines measured Study window 6 to 11 days What was measured Body-weight differences appeared during an 11-day obese-mouse study, with fat tissue measured at the end

This maintains the natural pulsatile pattern that the hypothalamic-pituitary axis expects, reducing the risk of desensitization

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At the primary level, host-related factors, including baseline metabolic status, insulin resistance, -cell function, inflammatory burden, and genetic background, represent the dominant drivers of therapeutic response