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Notably, a 2020 clinical trial involving patients with nonalcoholic steatohepatitis (NASH) revealed a 15% incidence of tumors (benign, malignant, or unspecified) (35/239) among those administered semaglutide, compared to 8% (6/80) in the control group [108]

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Linoleic acid inhibits in vitro function of human and murine dendritic cells, cd4(+)T cells and retinal pigment epithelial cells

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Transmembrane signal transduction by peptide hormones via family B G protein-coupled receptors

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Regulatory considerations also come into play, as natural products are not as rigorously regulated as pharmaceuticals

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