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461,462 Advances in automated cell manufacturing platforms and the shift from patient-specific CAR-T cells to off-the-shelf universal CAR-T cells are needed to reduce production time and cost, 462,463 making these therapies more accessible
The temporal pattern matters too
Once produced, TMA is absorbed into the bloodstream and transported to the liver, where it undergoes further oxidation to form TMAO via the enzyme FMO-3 [23, 25]
E., Dohna-Schwake, C., Hanssler, L., Neudorf, U., Hoyer, P
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