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FXR knockout mice show increased CYP7A1 expression and hepatic BA synthesis, suggesting that FXR primarily mediates the inhibitory effects of BA synthesis via CYP7A1 (Sinal et al., 2000)
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After propensity-score matching, the two cohorts (26,670 in each cohort, mean age 58.0 years, 45.3% women, 14.7% black, 60.3% white, 6.5% Hispanic) were balanced (Supplementary Table 1)
This scenario is whats happening far too regularly with B12 deficiency and the situation is down to lack of education and correct, clear information about this condition
