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Summary: Retatrutide commonly causes bowel changes including diarrhoea, constipation, and abdominal discomfort due to its activation of GLP-1 receptors throughout the gastrointestinal tract, which alters gut motility

Clinical Endocrinology Journal, 47(3), 210-219

As such, it stresses that regulating the food environment must remain a policy priority, with more evidence needed on longterm effects particularly for children and adolescents and on extended or repeated use

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