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Therapy should therefore not be discontinued in patients with established CVD who do not achieve the weight-loss targets observed in clinical trials
If a dose is missed and the next dose is more than 5 days away, take it as soon as remembered
The likely effect of the variation identified here is that towards the end of a weekly dosing period, those reduction effects will wear off
This finding aligns with prior evidence of autonomic involvement in RHR increases following acute GLP-1 RA administration in patients with type 2 diabetes (T2D) (16)
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