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The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis (Bays et al., NEJM 2025) reported 28.7% mean weight loss at 68 weeks at the 12 mg dose, plus a 75.8% reduction in WOMAC knee pain scores

PubChem SID: 12352200

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My protocol was straightforward: Retatrutide: 4 mg per week, subcutaneous injection (abdomen), every Saturday morning AOD-9604: 0.3 mg per day, subcutaneous injection (abdomen), every morning before eating Duration: 16 weeks of the combined stack Diet: High protein (90 to 100 grams daily), moderate carbs, 30 to 40 grams of healthy fats Activity: Walking 5 days a week, light resistance training 2 days Within the first two weeks of adding AOD-9604, I noticed my midsection felt different