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Amylin and Eli Lilly have also recently reported positive results from a small phase 2 study that compared their once-monthly GLP-1 formulation (referred to as exenatide once-monthly) to Bydureon
Gut 45, 592594 (1998)
This direct entry means the compound avoids enzymatic degradation in the gut and first-pass metabolism in the liver, both of which destroy the vast majority of peptide-based medications when swallowed
It also slows down how quickly the stomach empties, leading to a slower release of glucose into the bloodstream and increasing satiety
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