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Ultimately, they discovered the drug was able to reduce the risk for cardiovascular events by about 20% specifically in adults who are 45 and older, considered overweight or obese, not diabetic, and who have previously had a cardiovascular event

Those with established cardiovascular disease require careful monitoring but are not excluded from treatmentindeed, they may derive particular benefit from weight reduction and associated risk factor improvements

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NNMT is upregulated in obesity and cancer cachexia, and NNMT knockdown in mice protects against diet-induced obesity [2]