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Semaglutide 2.4mg (Wegovy) is commissioned by the NHS only through specialist weight management services, with specific eligibility criteria (including BMI thresholds, which are lower for people from some ethnic groups) and a maximum treatment duration of 2 years
Hepatocyte DACH1 is increased in obesity via nuclear exclusion of HDAC4 and promotes hepatic insulin resistance
Although not readily used in the UK due to ongoing regulatory ambiguities, they are increasingly prescribed in other countries and subject to intensive ongoing research
Compound 7J was found to have the best ferroptosis inhibitory activity by SAR study, 7J showed good ROS scavenging ability and could alleviate DOX-induced cardiotoxicity with a good pharmacokinetic profile and no significant toxicity in vitro and ex vivo (You et al., 2022)
