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A 2025 network meta-analysis of GLP-1 medications and co-agonists landed at roughly a quarter of total weight reduction coming from lean mass for both semaglutide and tirzepatide, which is close to what happens with placebo and standard weight loss
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Scenario 3: Denied for off-label use
In addition, there were statistically significant differences in pain scores (adjusted mean difference in WOMAC total score = 1.46
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