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Fernndez-Checa, Liver Unit, Hospital Clnic, Centre Esther Koplowitz, Institut dInvestigacions Biomdiques August Pi i Sunyer (IDIBAPS)Centro de Investigacin Biomdica en Red de Enfermedades Hepticas y Digestivas (CIBERehd), Planta Cuarta, C/Rossell 149, Barcelona 08036, Spain e-mail: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a Section of the journal Frontiers in Pharmacology

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This susceptibility poses a serious threat to human health, contributing to approximately 2 million deaths annually, accounting for 4% of global mortality ( 4 )-induced acute liver injury model is widely used because it effectively mimics human liver conditions, such as acute liver injury, fibrosis, and oxidative stress ( Current treatments for liver diseases include antioxidants, hepatoprotective agents, anti-inflammatory drugs, and antivirals, all aimed at preventing or mitigating liver damage ( Glutathione, a key molecule involved in maintaining cellular redox homeostasis, has shown promise in protecting the liver from oxidative damage in various liver disorders

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