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In practice, the experience is more complicated
Moving from insulin to GLP-1 A patient on basal insulin whose Type 2 diabetes is relatively well controlled might transition to a GLP-1 agonist if they are gaining excessive weight on insulin, want to simplify their regimen, have developed cardiovascular risk factors that would benefit from GLP-1 protection, or have adequate remaining beta cell function
Leg cramps are not listed as a recognized adverse effect in FDA prescribing information for semaglutide
The key is to be intentional about strength training, nutrition, and tracking progress over time
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