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A retrospective study conducted at the University Health Network found that, in liver transplant recipients with diabetes, combination therapy reduced HbA1c and alanine aminotransferase levels more effectively than DPP-4 inhibitors. Additionally, two clinical trials in patients with Type 2 diabetes demonstrated that combination therapy significantly lowered HbA1c by 1.34% and 1.21%, compared to a 0.54% reduction with placebo, starting from a baseline of 8.0%. These findings suggest that combination therapy may be especially beneficial in the liver transplant population, where patients often experience weight gain and develop metabolic co-morbidities
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In a neonatal rat model of hypoxic-ischemic injury, hippocampal neuron ferroptosis was shown to be triggered via TXNIP/Trx1/GPX4 pathway activation, which was directly associated with hypoxic-ischemic brain damage severity (104)
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This, in turn, triggers lipolysis, elevating free fatty acids and leading to increased -oxidation and ketone body accumulation [13]
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